Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits

LJ MacPherson, EK Bayburt…

Index: Journal of Medicinal Chemistry, , vol. 40, # 16 p. 2525 - 2532

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Citation Number: 332

Abstract

... Journal of Medicinal ... 8,9 For these reasons, stromelysin (along with collagenase and gelatinase) has become an important pharmaceutical target, 10-15 ... of NEP, it proved to be a potent inhibitor of stromelysin and formed the basis of the medicinal chemistry program outlined ...