A novel synthesis of 2??arylaminothiazolo [4, 5??d] pyridazinones

T Yamasaki, E Kawaminami, F Uchimura…

Index: Yamasaki, Tetsuo; Kawaminami, Eiji; Uchimura, Fumi; Okawara, Tadashi; Furukawa, Mitsuru Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 859 - 865

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Citation Number: 3

Abstract

Abstract The reaction of 5 (4)-amino-4 (5)-chloropyridazin-3 (2H)-ones 1 (9) with methyl dithiocarbamates 2 gave 2-arylaminothiazolo [4, 5-d] pyridazinones 3 (10). Treatment of 5 (4)-alkylamino-4 (5)-chloropyridazin-3 (2H)-ones 5 (12) with 2 afforded the corresponding 2- aryliminothiazolo [4, 5-d] pyridazinones 6 (13). Cyclization of 1a with phenylisothiocyanate produced 2-amino-and 2-iminothiazolo [4, 5-d] pyridazinones 3a and 16.

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