2-Phenoxyethanamine

Modify Date: 2024-01-02 10:58:21

2-Phenoxyethanamine Structure
2-Phenoxyethanamine structure
Common Name 2-Phenoxyethanamine
CAS Number 156-43-4 Molecular Weight 137.179
Density 1.0±0.1 g/cm3 Boiling Point 230.3±23.0 °C at 760 mmHg
Molecular Formula C8H11NO Melting Point 2-5 °C(lit.)
MSDS Chinese USA Flash Point 97.9±15.9 °C
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger

 Names

Name 4-ethoxyaniline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 230.3±23.0 °C at 760 mmHg
Melting Point 2-5 °C(lit.)
Molecular Formula C8H11NO
Molecular Weight 137.179
Flash Point 97.9±15.9 °C
Exact Mass 137.084061
PSA 35.25000
LogP 0.89
Vapour Pressure 0.1±0.5 mmHg at 25°C
Index of Refraction 1.527
Stability Stability Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents.
Water Solubility practically insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SI6465500
CHEMICAL NAME :
p-Phenetidine
CAS REGISTRY NUMBER :
156-43-4
BEILSTEIN REFERENCE NO. :
0606666
LAST UPDATED :
199807
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C8-H11-N-O
MOLECULAR WEIGHT :
137.20
WISWESSER LINE NOTATION :
ZR DO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Rinsed with water
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
487 mg/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
530 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
692 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2353 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - emphysema Kidney, Ureter, Bladder - hematuria
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1120 mg/kg/28D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15250 ug/kg/9W-I
TOXIC EFFECTS :
Blood - normocytic anemia Blood - methemoglobinemia-carboxyhemoglobin Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
45750 ug/kg/9W-I
TOXIC EFFECTS :
Blood - normocytic anemia Blood - methemoglobinemia-carboxyhemoglobin Blood - other changes

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
160 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4375 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 206 (estimated) No. of Female Employees: 23 (estimated)

 Safety Information

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H302-H311-H319-H332-H334
Precautionary Statements P261-P280-P305 + P351 + P338-P342 + P311
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;Xn:Harmful;
Risk Phrases R20/21/22;R23/24/25;R33;R36;R43;R68
Safety Phrases S28-S36/37-S45-S46
RIDADR UN 2311 6.1/PG 3
WGK Germany 1
RTECS SI6465500
Packaging Group III
Hazard Class 6.1
HS Code 29222200

 Synthetic Route

 Customs

HS Code 2922291000
Summary 2922291000 4-methoxyaniline。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

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 Synonyms

2-Phenoxyethanamine
4-Aminophenetole
p-Phenetidine
MFCD00007865
EINECS 205-855-5
2-Phenoxy-ethylamine
Ethanamine, 2-phenoxy-
Phenetidine
4-Ethoxyaniline
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