Synthesis of carboxylated flavonoids as new leads for LTD 4 antagonists

ME Zwaagstra, H Timmerman, RS Abdoelgafoer…

Index: Zwaagstra; Timmerman; Abdoelgafoer; Zhang European Journal of Medicinal Chemistry, 1996 , vol. 31, # 11 p. 861 - 874

Full Text: HTML

Citation Number: 22

Abstract

A series of 3′-and 5′-carboxylated chalcones, 6-or 8-carboxylated flavones and 6- carboxylated flavanones,-flavanols and-flavans were prepared. The compounds were tested for their inhibitory activities against leukotriene D4 (LTD4) induced contraction of guinea-pig ileum. A new and convenient synthetic route to 3-acetyl-2-hydroxybenzoic acid (1d), a key intermediate for the synthesis of 3′-carboxy-2′-hydroxychalcones and 8-carboxylated ...