Molecular pharmaceutics

Inhibition of human and bovine insulin fibril formation by designed peptide conjugates

NK Mishra, KB Joshi, S Verma

Index: Mishra, Narendra Kumar; Joshi, Khashti Ballabh; Verma, Sandeep Molecular Pharmaceutics, 2013 , vol. 10, # 10 p. 3903 - 3912

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Citation Number: 12

Abstract

The aggregation of insulin, to afford amyloidogenic fibers, is a well-studied phenomenon, which has interesting biological ramifications and pharmaceutical implications. These fibers have been ascribed an intriguing role in certain disease states and stability of pharmaceutical formulations of this hormone. The present study describes the design and inhibitory effects of novel peptide conjugates toward fibrillation of insulin as investigated ...