Di(N-succinimidyl)adipate

Modify Date: 2025-08-25 19:44:14

Di(N-succinimidyl)adipate Structure
Di(N-succinimidyl)adipate structure
 Common Name Di(N-succinimidyl)adipate
CAS Number 59156-70-6 Molecular Weight 340.28500
Density N/A Boiling Point N/A
Molecular Formula C14H16N2O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Di(N-succinimidyl)adipate


Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name bis(2,5-dioxopyrrolidin-1-yl) hexanedioate
Synonym More Synonyms

 Di(N-succinimidyl)adipate Biological Activity

Description Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C14H16N2O8
Molecular Weight 340.28500
Exact Mass 340.09100
PSA 127.36000
InChIKey LZZXZDMVRZJZST-UHFFFAOYSA-N
SMILES O=C(CCCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

adipic acid di-N-hydroxysuccinimide ester
di-(N-hydroxysuccinimidyl) adipate ester
bis(N-hydroxysuccinimidyl) adipate
disuccinimidyl adipate
bis(N-hydroxysuccinimidyl) adipic acid diester
Di(N-succinimidyl) adipate
adipic acid bis(succinimidyl) ester
2,5-Pyrrolidinedione,1,1'-[(1,6-dioxo-1,6-hexanediyl)bis(oxy)]bis
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