Archiv der Pharmazie

Preparation and diuretic properties of novel amiloride analogues

T Russ, W Ried, F Ullrich, E Mutschler

Index: Russ; Ried; Ullrich; Mutschler Archiv der Pharmazie, 1992 , vol. 325, # 12 p. 761 - 767

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Citation Number: 8

Abstract

Abstract Fifteen novel amiloride analogues were synthesized and their diuretic properties compared to amiloride and triamterene in white wistar rats. Whereas none of the 6- substituted derivatives exhibited significant natriuretic and antikaliuretic effects, five of the compounds modified in the 2-position were found equal or better than standards. The results are discussed with respect to chemical structure and physicochemical properties.