1, 1'-Bis [6-(trifluoromethyl) benzotriazolyl] oxalate (BTBO): a new reactive coupling reagent for the synthesis of dipeptides, esters, and thio esters

K Takeda, K Tsuboyama, K Yamaguchi…

Index: Takeda, Kazuyoshi; Tsuboyama, Kanoko; Yamaguchi, Keiko; Ogura, Haruo Journal of Organic Chemistry, 1985 , vol. 50, # 2 p. 273 - 275

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Citation Number: 18

Abstract

Preparation of amides, esters, and thio esters by coupling reactions is very important in organic synthesis, and many reagents for promoting coupling reactions by one-pot procedures have been reported. 2 In most cases, these coupling reactions are used to convert carboxylic acids into amides, esters, or thio esters. Most of the coupling reagents first react with the carboxylic acids to give activated intermediates which undergo subsequent ...

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