Evaluation of the antiallodynic, teratogenic and pharmacokinetic profile of stereoisomers of valnoctamide, an amide derivative of a chiral isomer of valproic acid

D Kaufmann, B Yagen, A Minert, B Wlodarczyk…

Index: Kaufmann, Dan; Yagen, Boris; Minert, Anne; Wlodarczyk, Bogdan; Finnell, Richard H.; Schurig, Volker; Devor, Marshall; Bialer, Meir Neuropharmacology, 2010 , vol. 58, # 8 p. 1228 - 1236

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Citation Number: 22

Abstract

The purpose of this study was to evaluate the stereoselective pain relieving (antiallodynic) activity, antiallodynic–anticonvulsant correlation, teratogenicity and pharmacokinetic profile of two stereoisomers of valnoctamide (VCD), a CNS-active amide derivative of a chiral isomer of valproic acid (VPA). The individual stereoisomers (diastereomers),(2R, 3S)-VCD and (2S, 3S)-VCD were synthesized and their antiallodynic activity was evaluated in rats ...