Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists

YJ Zhang, LL Shen, HG Cheon, YN Xu…

Index: Zhang, Yu-Juan; Shen, Liu-Lan; Cheon, Hyae-Gyeong; Xu, Yong-Nan; Jeong, Jin-Hyun Archives of Pharmacal Research, 2014 , vol. 37, # 5 p. 588 - 599

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Citation Number: 3

Abstract

Abstract In this study, a series of fused-heterocyclic derivatives were systematically designed and synthesized using an efficient route, and evaluated in terms of GLP-1R agonist activity. We employed short synthetic steps and reactions that are tolerant of the presence of various functional groups and suitable for parallel operations to enable the rapid generation of libraries of diverse and structurally complex small molecules. Of the compounds ...