Pharmacology & toxicology

In vitro Metabolism of Two Heterocyclic Amines, 2??Amino??9H??pyrido [2, 3??b] indole (AαC) and 2??Amino??3??methyl??9H??pyrido [2, 3??b] indole (MeAαC) in …

H Frederiksen, H Frandsen

Index: Frederiksen, Hanne; Frandsen, Henrik Pharmacology and Toxicology, 2002 , vol. 90, # 3 p. 127 - 134

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Citation Number: 13

Abstract

Abstract: 2-Amino-9H-pyrido [2, 3-b] indole (AαC) and 2-amino-3-methyl-9H-pyrido [2, 3-b] indole (MeAαC) are two mutagenic and carcinogenic heterocyclic amines formed during ordinary cooking. In this study, we have investigated the in vitro metabolism of tritium- labelled AαC and MeAαC in hepatic microsomes from human pools, rats induced with polychlorinated biphenyl (PCB)(Aroclor 1254) and control rats. The microsomes were ...