Synthesis of lactivicin and its derivatives

H Natsugari, Y Kawano, A Morimoto…

Index: Natsugari, Hideaki; Kawano, Yasuhiko; Morimoto, Akira; Yoshioka, Kouichi; Ochiai, Michihiko Journal of the Chemical Society, Chemical Communications, 1987 , # 2 p. 62 - 63

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Citation Number: 14

Abstract

Hideaki Natsugari," Yasuhiko Kawano, Akira Morimoto, Kouichi Yoshioka, and Michihiko Ochiai Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd., Yodogawa-ku, Osaka 532, Japan ... Lactivicin, a new type of antibiotic having P-lactam-like activity, and its derivatives were synthesized starting from 4-benzyloxycarbonylamino-3-isoxazolidinones and 2-oxoglutaric acid. ... Lactivicinl (1) { 2-[ (4S)-4-acetamido-3-oxo-2-isoxazolidinyl]- 5- ...