Steroids
First synthesis of 3, 16, 20-polyoxygenated cholestanes, new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa
S Boonananwong, B Kongkathip, N Kongkathip
Index: Boonananwong, Suthinee; Kongkathip, Boonsong; Kongkathip, Ngampong Steroids, 2008 , vol. 73, # 11 p. 1123 - 1127
Full Text: HTML
Citation Number: 16
Abstract
Using tigogenin as starting material,(20S)-20-hydroxycholestane-3, 6-dione (1),(16S, 20S)- 16, 20-dihydroxycholestan-3-one (2),(20S)-20-hydroxycholest-1-ene-3, 16-dione (3) and (20S)-20-hydroxycholest-4-ene-3, 16-dione (4), natural polyoxygenated steroids from the gorgonian, Leptogorgia sarmentosa, were synthesized in four steps. Antitumor activity against three tumor cell lines (breast cancer, MCF7, lung cancer NCI and oral cancer KB) ...