Semisynthesis of triptolide analogues: Effect of γ-lactone and C-14 substituents on cytotoxic activities

Y Aoyagi, Y Hitotsuyanagi, T Hasuda, H Fukaya…

Index: Aoyagi, Yutaka; Hitotsuyanagi, Yukio; Hasuda, Tomoyo; Fukaya, Haruhiko; Takeya, Koichi; Aiyama, Ritsuo; Matsuzaki, Takeshi; Hashimoto, Shusuke Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3046 - 3049

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Citation Number: 6

Abstract

Abstract Triptolide γ-lactone and C-14 analogues were prepared and evaluated cytotoxity against human lung adenocarcinoma epithelial A549 cells and human colon adenocarcinoma HT-29 cells. γ-Lactone substructure and C-14 substituents affected the biological activities significantly.