Synthesis and NMR Binding Studies towards Rational Design of a Series of Electron??Withdrawing Diamide Receptors/Organocatalysts

M Kinsella, PG Duggan, J Muldoon…

Index: Kinsella, Michael; Duggan, Patrick G.; Muldoon, Jimmy; Eccles, Kevin S.; Lawrence, Simon E.; Lennon, Claire M. European Journal of Organic Chemistry, 2011 , # 6 p. 1125 - 1132

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Citation Number: 8

Abstract

Abstract A related series of bisamides have been evaluated for rational correlation between anion complexation and organocatalysis: remarkable enhancement of hydrogen bonding to anions was observed along with significant increases in catalytic activity in the Baylis– Hillman reaction. In addition, X-ray crystallography showed a large degree of pre- organisation was observed in one receptor by incorporation of bis (trifluoromethyl) aniline ...