Synthesis and antihyperglycemic evaluation of various protoberberine derivatives
X Bian, L He, G Yang
Index: Bian, Xiaoli; He, Langchong; Yang, Guangde Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1380 - 1383
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Citation Number: 39
Abstract
Various berberine derivatives (2–17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan- induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure–activity relationships were discussed.
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