palmatine

Modify Date: 2025-08-20 17:50:13

palmatine Structure
palmatine structure
 Common Name palmatine
CAS Number 3486-67-7 Molecular Weight 352.403
Density N/A Boiling Point N/A
Molecular Formula C21H22NO4+ Melting Point 205ºC
MSDS N/A Flash Point N/A

 Use of palmatine


Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].

 Names

Name palmatine
Synonym More Synonyms

 palmatine Biological Activity

Description Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].
Related Catalog
Target

IDO1

In Vitro Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM[1].
In Vivo Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1]. Animal Model: DSS- induced Colitis BALB/c mice model[1] Dosage: 50 or 100 mg/kg; 7 days Administration: Oral administration Result: Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells.
References

[1]. Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46.

 Chemical & Physical Properties

Melting Point 205ºC
Molecular Formula C21H22NO4+
Molecular Weight 352.403
Exact Mass 352.154327
PSA 40.80000
LogP -1.12

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9890000
CHEMICAL NAME :
Berbinium, 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-
CAS REGISTRY NUMBER :
3486-67-7
BEILSTEIN REFERENCE NO. :
1555498
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H22-N-O4
MOLECULAR WEIGHT :
352.44
WISWESSER LINE NOTATION :
T D6 B666 KN&TT&J GO1 HO1 PO1 QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,129,1968

 Safety Information

Hazard Codes Xi
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Calystigine
7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium
MFCD00221758
palmatine
Burasaine
2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium
palmatin
berbericinine
7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium
Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-
o,o-dimethyldemethyleneberberine
Hindarinine
5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium
Common fibraurea stem
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

palmatine suppliers

Price: ￥468/25mg

Reference only. check more palmatine price

Related Compounds: More...
palmatine iodide
4880-79-9
PALMATINE CHLORIDE
947153-64-2
Palmatine chloride
10605-02-4
Palmatine hydroxide
131-04-4
Palmatine hydrochloride
171869-95-7
N-(1-cyanocyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}acetamide
1210994-20-9
N-(5-bromopyridin-2-yl)-3,5-dimethyl-1,2-oxazole-4-sulfonamide
942765-03-9
N-(1-cyanocyclohexyl)-2-[(3-ethynylphenyl)amino]acetamide
1210937-24-8
Ethanone, 1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-[(3-ethynylphenyl)amino]-
1154914-96-1
3-({[(1-cyanocyclohexyl)carbamoyl]methyl}amino)-N,N-dimethylbenzamide
1241659-15-3
7-(4-acetylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-N-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxamide
1092326-40-3
4-butyl-N-(4-pyridinylmethyl)cyclohexanecarboxamide
905783-77-9
3-(1-Cyclopropanecarbonyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-(3,4-dichlorophenyl)urea
1203207-54-8
5-(((3,4-Dimethoxyphenyl)sulfonyl)methyl)-3-(o-tolyl)-1,2,4-oxadiazole
1105234-36-3
Tert-butyl 4-[(tert-butylamino)methyl]-4-hydroxy-piperidine-1-carboxylate
1181662-85-0
Chemsrc provides palmatine(CAS#:3486-67-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of palmatine are included as well.>> amp version: palmatine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved