Synthesis and antimicrobial activity of derivatives of 2-aryl-3, 4-bis (carboxy) furans

…, EV Adamskaya, OV Okinshevich, GN Pershin

Index: Oleinik, A. F.; Adamskaya, E. V.; Okinshevich, O. V.; Pershin, G. N. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 6 p. 408 - 410 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 6 p. 683 - 685

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Abstract

Derivatives of 2-aryl-3, 4-bis (carbomethoxy) furans (Ilia and 5) gave the corresponding acids la and b, which with thionyl chloride in the presence of a catalytic amount of DMFA were converted to the acid dichlorides (lla and b). In the absence of DMFA, Ib formed the anhydride of 2-(p-anisyl)-3, 4-bis (carboxy) furan. The diamines (IVa and b) were obtained from lla and b. With hydrazine, lla and b were converted into the cyclic hydrazides (Va and ...