Synthesis and Dual 5-HT1A/SSRI Activities of Some Novel Arylpiperazine Derivatives of Duloxetine

S Chen, A Li, M Chen

Index: Chen, Shao-Rui; Li, Ai-Jun; Chen, Ming-Ming Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1680 - 1684

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Abstract

Abstract A series of novel arylpiperazine derivatives of duloxetine were designed and synthesized from the key intermediate 5 by acylation, alkylation and reduction based on 5- HT1A/SSRI drugs design strategies. Compound 5 was obtained through the reaction sequence including condensation, reduction, O-etherification, Von Braun reaction, hydrolysis reaction. Structures of the synthesized compounds were confirmed by MS, 1H ...