Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor

…, M Sturgess, M Goeldner, B Foucaud

Index: Kreimeyer, Annett; Laube, Bodo; Sturgess, Mike; Goeldner, Maurice; Foucaud, Bernard Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4394 - 4404

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Citation Number: 35

Abstract

The glycine-binding site of the N-methyl-d-aspartate (NMDA) receptor, given its potential as pharmacological target, has been thoroughly studied by structure-activity relationships, which has made possible its description in terms of spatial limits and interactions of various types. A structural model, based on mutational analysis and sequence alignements, has been proposed. Yet, the amino acid residues responsible for the interactions with the ...