Technology of preparing 8-hydroxy-5-nitroquinoline

…, II Lomovskii, KG Korolev, RK Karimov

Index: Isaev; Lomovskii; Korolev; Karimov Chemistry of Heterocyclic Compounds, 2005 , vol. 41, # 8 p. 1027 - 1030

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Citation Number: 11

Abstract

Abstract An efficient, two stage method is proposed for the preparation of 8-hydroxy-5- nitroquinoline based on the nitrosation of 8-hydroxyquinoline and subsequent oxidation of the nitroso derivative using nitric acid. The conditions for the nitrosation and oxidation of the 8-hydroxyquinoline (concentration of nitric acid, temperature, and reaction time) were optimized. A method for purifying the target compound is presented.