Tetrahedron

An efficient synthesis of the phytoestrogen 8-prenylnaringenin from isoxanthohumol with magnesium iodide etherate

M Anioł, K Szymańska, A Żołnierczyk

Index: Aniol, Miroslaw; Szymanska, Katarzyna; Zolnierczyk, Anna Tetrahedron, 2008 , vol. 64, # 40 p. 9544 - 9547

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Citation Number: 18

Abstract

Xanthohumol was isolated from supercritical carbon dioxide–spent hop and transformed into isoxanthohumol. The demethylation of isoxanthohumol with the best yield 93% occurred when MgI2 etherate in anhydrous THF was applied. Salts such as MgBr2, MgCl2, CaI2, Mg (OAc) 2, Mg (OMe) 2 were also investigated. A convenient method for the xanthohumol isolation from supercritical carbon dioxide–spent hop is also described.