Medicinal Chemistry Research

Synthesis and cytotoxicity of novel chrysin derivatives

K Hu, W Wang, H Cheng, SS Pan, J Ren

Index: Hu, Kun; Wang, Wei; Cheng, Hong; Pan, ShaSha; Ren, Jie Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 838 - 846

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Citation Number: 17

Abstract

Abstract A series of chrysin derivatives 8a–8v were prepared and tested in vitro against HCT- 116 (human colon cancer cell line), Hela (human cervical carcinoma cell line), DU-145 (human prostate cell line), K562 (human leukemia cell line), and SGC-7901 (human gastric cancer cell line). The chemical structures of these compounds were confirmed by means of MS, IR, 1 H NMR, 13 C NMR, and elemental analysis. Among these derivatives, 7-(2-( ...

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