Chrysin

Modify Date: 2024-01-02 13:45:20

Chrysin Structure
Chrysin structure
 Common Name Chrysin
CAS Number 480-40-0 Molecular Weight 254.238
Density 1.4±0.1 g/cm3 Boiling Point 491.9±45.0 °C at 760 mmHg
Molecular Formula C15H10O4 Melting Point 284-286 °C(lit.)
MSDS Chinese USA Flash Point 192.5±22.2 °C

 Use of Chrysin


Chrysin is one of the most well known estrogen blockers.

 Names

Name chrysin
Synonym More Synonyms

 Chrysin Biological Activity

Description Chrysin is one of the most well known estrogen blockers.
Related Catalog
Target

estrogen

In Vitro Chrysin is mainly found in passion flowers, honey, and propolis acts as a potential therapeutic and preventive agent to inhibit proliferation and invasion of various human cancer cells. Although Chrysin has anti-carcinogenic effects in several cancers, little is known about its functional roles in ovarian cancer which shows poor prognosis and chemoresistance to traditional therapeutic agents. Chrysin inhibits ovarian cancer cell proliferation and induced cell death by increasing reactive oxygen species (ROS) production and cytoplasmic Ca2+ levels as well as inducing loss of mitochondrial membrane potential (MMP). Chrysin activates MAPK and PI3K/AKT pathways in ES2 and OV90 cells in concentration-response experiments. Chrysin suppresses tumor growth byregulating canonical Wnt and nuclear factor NF-κB signaling cascades cancer cells. Chrysin stimulates the phosphorylation of AKT and P70S6K proteins in both ES2 and OV90 cells compared tothe untreated control cells. In addition, Chrysin activates the phospho-ERK1/2, p38,and JNK proteins as members of the MAPK pathway in the ovarian cancer cells[1].
Cell Assay The proliferation assays are conducted using a cell proliferation enzyme-linked immunosorbent assay (ELISA) 5-bromo-2'-deoxyuridine (BrdU) kit. Briefly, ES2 and OV90 cells are seeded in a 96-well plate, and then treated with Chrysin (0, 5, 10, 20, 50, and 100 µM) with or without inhibitors (20 μM LY294002, PI3K/AKT; 10 μM U0126, ERK1/2; 10 μM SP600125, JNK; and 20 μM SB203580, p38) in a final volume of 100 μL/well. Aftera48-h incubation, 10 μM BrdU is added to the cell culture, followed by an additional 2-h incubation at 37°C. After labeling the cells with BrdU, they are fixed and then incubated with the anti-BrdU-peroxidase (POD) working solution for 90 min. The anti-BrdU-POD binds to the BrdU incorporated into newly synthesized cellular DNA and these immune complexes are detected by analyzing their reaction with the 3,3',5,5'-tetramethylbenzidine (TMB) substrate. The absorbance values of the reaction product are measured at 370 and 492 nm using an ELISA reader[1].
References

[1]. Lim W, et al. Chrysin Attenuates Progression of Ovarian Cancer Cells by Regulating Signaling Cascades and Mitochondrial Dysfunction. J Cell Physiol. 2017 Aug 17.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 491.9±45.0 °C at 760 mmHg
Melting Point 284-286 °C(lit.)
Molecular Formula C15H10O4
Molecular Weight 254.238
Flash Point 192.5±22.2 °C
Exact Mass 254.057907
PSA 70.67000
LogP 2.88
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.699
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LK8329050
CHEMICAL NAME :
Flavone, 5,7-dihydroxy-
CAS REGISTRY NUMBER :
480-40-0
BEILSTEIN REFERENCE NO. :
0233276
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H10-O4
MOLECULAR WEIGHT :
254.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Fibroblast
DOSE/DURATION :
100 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 33,3823,1984

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LK8329050
HS Code 2914400090

 Synthetic Route

 Customs

HS Code 2914400090
Summary 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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 Synonyms

5,7-Dihydroxyflavone
Chrysin
5,7-dihydroxy-2-phenylchromen-4-one
EINECS 207-549-7
5,7-Dihydroxy-2-phenyl-4H-chromen-4-one
MFCD00006834
Chrysidenon 1438
Chrysinic acid
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-phenyl-
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