A convenient general procedure for the conversion of alcohols into their monophosphate esters

TA Khwaja, CB Reese, JCM Stewart

Index: Khwaja,T.A. et al. Journal of the Chemical Society [Section] C: Organic, 1970 , p. 2092 - 2100

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Citation Number: 32

Abstract

o-Phenylene phosphorochloridate (IV), readily prepared from catechol in good yield, reacts rapidly and quantitatively with stoicheiometric amounts of alcohols (including tertiary alcohols) in the presence of a suitable base (triethylamine or 2, 6-lutidine) and in a suitable solvent (dioxan, tetrahydrofuran, or benzene). Alkyl o-hydroxyphenyl phosphate salts (IX) were thus obtained in virtually quantitative yields, and sometimes as pure crystalline ...