2-(N'-alkylidenehydrazino) adenosines: potent and selective coronary vasodilators

K Niiya, RA Olsson, RD Thompson…

Index: Niiya; Olsson; Thompson; Silvia; Ueeda Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4557 - 4561

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Citation Number: 80

Abstract

The reaction of aliphatic aldehydes and ketones with 2-hydrazinoadenosine under relatively mild conditions (at room temperature or in refluxing methanol) formed 2-(N/- alkylidenehydrazino)-adenosines, 5-22, in good yields. Two kinds of adenosine receptors regulate cardiac and coronary physiology. In supraventricular tissues an AlAR coupled to muscarinic K channels mediates the negative chronotropic, dromotropic, and inotropic ...

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