2-Hydrazinyl-adenosine

Modify Date: 2024-01-19 15:08:40

2-Hydrazinyl-adenosine Structure
2-Hydrazinyl-adenosine structure
 Common Name 2-Hydrazinyl-adenosine
CAS Number 15763-11-8 Molecular Weight 297.27
Density 2.29±0.1 g/cm3(Predicted) Boiling Point 583.1±60.0 °C(Predicted)
Molecular Formula C10H15N7O4 Melting Point 208-210ºC
MSDS N/A Flash Point N/A

 Use of 2-Hydrazinyl-adenosine


2-Hydrazinyl-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2-Hydrazino Adenosine
Synonym More Synonyms

 2-Hydrazinyl-adenosine Biological Activity

Description 2-Hydrazinyl-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 2.29±0.1 g/cm3(Predicted)
Boiling Point 583.1±60.0 °C(Predicted)
Melting Point 208-210ºC
Molecular Formula C10H15N7O4
Molecular Weight 297.27
Exact Mass 297.11900
PSA 177.59000
Index of Refraction 2.002
Storage condition 2-8°C

 Safety Information

Hazard Codes Xn

 Synthetic Route

2-Fluoroadenosine structure

2-Fluoroadenosine

CAS#:146-78-1

~94%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: RELIABLE BIOPHARMACEUTICAL CORPORATION; WOOLDRIDGE, Luzviminda, T.; MA, Chun; NADJI, Sourena Patent: WO2012/149196 A1, 2012 ; Location in patent: Page/Page column 17 ;
2-Chloroadenosine structure

2-Chloroadenosine

CAS#:146-77-0

~82%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: CV THERAPEUTICS, INC. Patent: WO2008/143667 A1, 2008 ; Location in patent: Page/Page column 20-21 ; WO 2008/143667 A1
2-Iodoadenosine structure

2-Iodoadenosine

CAS#:35109-88-7

~83%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: Van Tilburg, Erica W.; Von Frijtag Drabbe Kuenzel, Jacobien; De Groote, Miriam; IJzerman, Ad P. Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 420 - 429
2-CHLORO-6-AMINO-9-(2',3',5'-TRI-O-ACETYL-?-D-RIBOFURANOSYL)PURINE structure

2-CHLORO-6-AMIN...

CAS#:79999-39-6

~88%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: Niiya; Olsson; Thompson; Silvia; Ueeda Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4557 - 4561
Inosine,2-chloro-6-O-methyl- (9CI) structure

Inosine,2-chlor...

CAS#:15465-92-6

~%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: Schaeffer; Thomas Journal of the American Chemical Society, 1958 , vol. 80, p. 3738,3741
Guanosine structure

Guanosine

CAS#:118-00-3

~%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447
2',3',5'-Triacetylguanosine structure

2',3',5'-Triace...

CAS#:6979-94-8

~%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447
2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside structure

2',3',5'-Tri-O-...

CAS#:16321-99-6

~%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447
9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

~%

2-Hydrazinyl-adenosine Structure

2-Hydrazinyl-ad...

CAS#:15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447

 Synonyms

(2R,3R,4S,5R)-2-(6-amino-2-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
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