The Journal of Organic Chemistry

Reagents for combinatorial organic synthesis: development of a new o-nitrobenzyl photolabile linker for solid phase synthesis

CP Holmes, DG Jones

Index: Holmes, Christopher P.; Jones, David G. Journal of Organic Chemistry, 1995 , vol. 60, # 8 p. 2318 - 2319

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Citation Number: 261

Abstract

1 acid has been the most widely employed photolabile support for the generation of both peptide acids and amides. 2 Photolabile amide protecting groups for C-termini of peptides which rely on the same basic o-nitrohenzyl chemistry have also been rep~ rted.~ The rapidly growing field of combinatorial organic synthesis4 involving libraries of peptides and small molecules has markedly renewed interest in the use of photolabile linkers for the release ...