Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors

J N'gompaza-Diarra, K Bettayeb, N Gresh…

Index: N'Gompaza-Diarra, Joannah; Bettayeb, Karima; Gresh, Nohad; Meijer, Laurent; Oumata, Nassima European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 210 - 216

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Citation Number: 3

Abstract

A new series of 2, 6, 9-trisubstituted purines, structurally related to the cyclin-dependent kinase (CDK) inhibitor Roscovitine, has been synthesized. These compounds mainly differ by the substituent on the C-2 position which encompasses a diol group. These compounds were screened for kinase inhibitory activities and antiproliferative effects. They were shown to be potent inhibitors of cyclin-dependent kinases but also, for some of them of casein ...

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