Journal of fluorine chemistry

The synthesis of difluoro and trifluoro analogues of pyrimidine deoxyribonucleosides: a novel approach using elemental fluorine

PL Coe, RR Talekar, RT Walker

Index: Coe, Paul L.; Talekar, Ratnakar R.; Walker, Richard T. Journal of Fluorine Chemistry, 1994 , vol. 69, # 1 p. 19 - 24

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Citation Number: 10

Abstract

Abstract The preparation of some novel fluorodeoxy nucleosides in good yields by the fluorination of unsaturated intact nucleosides with elemental fluorine at− 78 C in mixtures of chloroform, ethanol and fluorotrichloromethane is described. This is the first example of the fluorination of an intact nucleoside by elemental fluorine and represents a considerable step forward in the use of the element in the synthesis of bioactive species. Thus, we were able ...