Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI)

Modify Date: 2024-01-13 11:18:10

Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI) Structure
Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI) structure
Common Name Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI)
CAS Number 15379-29-0 Molecular Weight 228.18
Density 1.57g/cm3 Boiling Point N/A
Molecular Formula C9H9FN2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI)


2′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione
Synonym More Synonyms

  Biological Activity

Description 2′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.57g/cm3
Molecular Formula C9H9FN2O4
Molecular Weight 228.18
Exact Mass 228.05500
PSA 84.32000
Index of Refraction 1.609

 Synthetic Route

~75%

Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI) Structure

Uridine, 2',3'-...

CAS#:15379-29-0

Literature: Joshi, Bhalchandra V.; Rao, T. Sudhakar; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 19 p. 2537 - 2544

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Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI) Structure

Uridine, 2',3'-...

CAS#:15379-29-0

Literature: Coe, Paul L.; Talekar, Ratnakar R.; Walker, Richard T. Journal of Fluorine Chemistry, 1994 , vol. 69, # 1 p. 19 - 24

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Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI) Structure

Uridine, 2',3'-...

CAS#:15379-29-0

Literature: Joshi, Bhalchandra V.; Rao, T. Sudhakar; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 19 p. 2537 - 2544

 Synonyms

2',3'-Didehydro-2',3'-dideoxy-hexopyranosyl cytidine