Solution forms of bouvardin and relatives from NMR studies. 6-O-Methylbouvardin

RB Bates, JR Cole, JJ Hoffmann, GR Kriek…

Index: Bates,R.B.; Cole,J.R.; Hoffmann,J.J. Journal of the American Chemical Society, 1983 , vol. 105, p. 1343

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Citation Number: 60

Abstract

Abstract:'H and I3C NMR studies indicate that the predominant stereoisomer and conformer in solution for the potent natural antitumor agents deoxybouvardin (l), bouvardin (2), and the newly isolated and equally active 6-0-methylbouvardin (3) is that found in the solid state by X-ray diffraction. Unusual features in the spectra, all in the vicinity of the 14-membered ring, include an aromatic proton absorbing unusually far upfield at S 4.35, a vicinal HC-0-H ...