Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity

S Vogel, S Ohmayer, G Brunner, J Heilmann

Index: Vogel, Susanne; Ohmayer, Susanne; Brunner, Gabi; Heilmann, Joerg Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4286 - 4293

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Citation Number: 152

Abstract

A general strategy for the synthesis of 3′-prenylated chalcones was established and a series of prenylated hydroxychalcones, including the hop (Humulus lupulus L.) secondary metabolites xanthohumol (1), desmethylxanthohumol (2), xanthogalenol (3), and 4- methylxanthohumol (4) were synthesized. The influence of the A-ring hydroxylation pattern on the cytotoxic activity of the prenylated chalcones was investigated in a HeLa cell line ...