Helichrysetin
Helichrysetin structure
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Common Name | Helichrysetin | ||
|---|---|---|---|---|
| CAS Number | 62014-87-3 | Molecular Weight | 286.279 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 532.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H14O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 201.0±23.6 °C | |
Use of HelichrysetinHelichrysetin, isolated from the flowers of Helichrysum odoratissimum, is an ID2 (inhibitor of DNA binding 2) inhibitor, and suppresses DCIS (ductal carcinoma in situ) formation. Helichrysetin possess strong inhibitory effects on cell growth and is capable of inducing apoptosis in A549 cells[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Helichrysetin, isolated from the flowers of Helichrysum odoratissimum, is an ID2 (inhibitor of DNA binding 2) inhibitor, and suppresses DCIS (ductal carcinoma in situ) formation. Helichrysetin possess strong inhibitory effects on cell growth and is capable of inducing apoptosis in A549 cells[1][2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 532.0±50.0 °C at 760 mmHg |
| Molecular Formula | C16H14O5 |
| Molecular Weight | 286.279 |
| Flash Point | 201.0±23.6 °C |
| Exact Mass | 286.084137 |
| PSA | 86.99000 |
| LogP | 3.08 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.684 |
| InChIKey | OWGUBYRKZATRIT-QPJJXVBHSA-N |
| SMILES | COc1cc(O)cc(O)c1C(=O)C=Cc1ccc(O)cc1 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| HS Code | 2914509090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~53%
Helichrysetin CAS#:62014-87-3 |
| Literature: Aponte, Jose C.; Castillo, Denis; Estevez, Yannick; Gonzalez, German; Arevalo, Jorge; Hammond, Gerald B.; Sauvain, Michel Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 100 - 103 |
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~74%
Helichrysetin CAS#:62014-87-3 |
| Literature: Vogel, Susanne; Ohmayer, Susanne; Brunner, Gabi; Heilmann, Joerg Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4286 - 4293 |
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~%
Helichrysetin CAS#:62014-87-3 |
| Literature: Zemplen et al. Chemische Berichte, 1944 , vol. 77/79, p. 446,449 |
![(2E)-1-[2-methoxy-4,6-bis(2-propenyloxy)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one structure](https://image.chemsrc.com/caspic/479/1070781-94-0.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
|---|---|
| DownStream 2 | |
CAS#:3420-72-2
CAS#:37308-75-1This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Helichrysetin |
| 4',6'-dihydroxy-2',4-dimethoxychalcone |
| (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one |
| (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one |
| 6'-O-methylisosalipurpol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: SMILES notation of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one is COc1cc(O)cc(O)c1C(=O)C=Cc1ccc(O)cc1. |
| Q: What is the English name of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: The English name of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one is (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one. |
| Q: What is the InChIKey of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: InChIKey of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one is OWGUBYRKZATRIT-QPJJXVBHSA-N. |
| Q: What are the uses of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: Main uses of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one: Helichrysetin, isolated from the flowers of Helichrysum odoratissimum, is an ID2 (inhibitor of DNA binding 2) inhibitor, and suppresses DCIS (ductal carcinoma in situ) formation. Helichrysetin possess strong inhibitory effects on cell growth and is capable of inducing apoptosis in A549 cells[1][2]. |
| Q: What is the CAS number of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: CAS number of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one is 62014-87-3. |
| Q: What is the LogP of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: LogP of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one is 3.08. |
| Q: What are the downstream products of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: Related downstream products(CAS) of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one: 3420-72-2;37308-75-1. |
| Q: What is the molecular formula of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: Molecular formula of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one is C16H14O5. |
| Q: What is the boiling point of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: Boiling point of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one is 532.0±50.0 °C at 760 mmHg. |
| Q: What are the upstream materials of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one? |
| A: Related upstream materials(CAS) of (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one: 1070781-94-0;123-08-0. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |