Helichrysetin

Modify Date: 2025-09-04 17:13:10

Helichrysetin structure	Common Name	Helichrysetin
	CAS Number	62014-87-3	Molecular Weight	286.279
	Density	1.4±0.1 g/cm3	Boiling Point	532.0±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	201.0±23.6 °C

Use of Helichrysetin

Helichrysetin, isolated from the flowers of Helichrysum odoratissimum, is an ID2 (inhibitor of DNA binding 2) inhibitor, and suppresses DCIS (ductal carcinoma in situ) formation. Helichrysetin possess strong inhibitory effects on cell growth and is capable of inducing apoptosis in A549 cells[1][2].

Name	(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-prop en-1-one
Synonym	More Synonyms

Description	Helichrysetin, isolated from the flowers of Helichrysum odoratissimum, is an ID2 (inhibitor of DNA binding 2) inhibitor, and suppresses DCIS (ductal carcinoma in situ) formation. Helichrysetin possess strong inhibitory effects on cell growth and is capable of inducing apoptosis in A549 cells[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Liu Y, et al. ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness. Breast Cancer Res Treat. 2019 May;175(1):77-90. [2]. Ho YF, et al. Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells. Evid Based Complement Alternat Med. 2013;2013:857257.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Liu Y, et al. ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness. Breast Cancer Res Treat. 2019 May;175(1):77-90.

[2]. Ho YF, et al. Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells. Evid Based Complement Alternat Med. 2013;2013:857257.

Density	1.4±0.1 g/cm3
Boiling Point	532.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₄O₅
Molecular Weight	286.279
Flash Point	201.0±23.6 °C
Exact Mass	286.084137
PSA	86.99000
LogP	3.08
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.684
InChIKey	OWGUBYRKZATRIT-QPJJXVBHSA-N
SMILES	COc1cc(O)cc(O)c1C(=O)C=Cc1ccc(O)cc1

Hazard Codes	Xi
HS Code	2914509090

(2E)-1-[2-metho...

CAS#:1070781-94-0

~53%

Helichrysetin

CAS#:62014-87-3

Literature: Aponte, Jose C.; Castillo, Denis; Estevez, Yannick; Gonzalez, German; Arevalo, Jorge; Hammond, Gerald B.; Sauvain, Michel Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 100 - 103

(E)-1-(2-methox...

CAS#:1034276-39-5

~74%

Helichrysetin

CAS#:62014-87-3

Literature: Vogel, Susanne; Ohmayer, Susanne; Brunner, Gabi; Heilmann, Joerg Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4286 - 4293

4-hydroxybenzal...

CAS#:123-08-0

Helichrysetin

CAS#:62014-87-3

Literature: Zemplen et al. Chemische Berichte, 1944 , vol. 77/79, p. 446,449

Precursor 2
CAS#:1070781-94-0 (2E)-1-[2-metho... CAS#:123-08-0 4-hydroxybenzal...
DownStream 2
CAS#:3420-72-2 Flavokawain A CAS#:37308-75-1 Flavokawain C

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Name: Antiproliferative activity against human HT1080 cells by MTT assay
Source: ChEMBL
Target: HT-1080
External Id: CHEMBL950663

Name: Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation af...
Source: ChEMBL
Target: HeLa
External Id: CHEMBL3418924

Name: Antiproliferative activity against mouse Colon 26-L5 cells by MTT assay
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL950662

Name: Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation a...
Source: ChEMBL
Target: HepG2
External Id: CHEMBL3418925

Name: Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation af...
Source: ChEMBL
Target: A549
External Id: CHEMBL3418923

Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data

Name: Cytotoxicity against human HeLa cells by MTT assay
Source: ChEMBL
Target: HeLa
External Id: CHEMBL983405

Name: Inhibition of TNFalpha/IL-1beta-induced NFkB p65 translocation from cytosol to nucleu...
Source: ChEMBL
Target: Transcription factor p65
External Id: CHEMBL4334113

Name: Toxicity against BALB/c mouse macrophage by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1048716

Name: Antioxidant activity assessed as trolox equivalent at 0.1 to 1 uM by ORAC-fluorescein...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL983408

Total 17, Current Page 1 of 2

Helichrysetin

4',6'-dihydroxy-2',4-dimethoxychalcone

(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one

(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

6'-O-methylisosalipurpol

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