Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor

X Chen, L Li, F Liu, B Liu

Index: Chen, Xiangji; Li, Liang; Liu, Fei; Liu, Boli Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5503 - 5506

Full Text: HTML

Citation Number: 63

Abstract

Three deoxyglucose (DG) derivatives, S-DG, MAG3-DG and MAMA-BA-DG, were synthesized and labeled successfully with high labeling yields and high radio-chemical purities. Biodistribution in tumor-bearing mice demonstrated that these three new 99mTc- deoxyglucose derivatives showed accumulation in tumor and high tumor-to-muscle ratios. Among them, the 99mTc-MAG3-DG showed the best characteristics as a potential tumor ...