Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids

JR Pfister, WE Wymann, JM Mahoney…

Index: Pfister; Wymann; Mahoney; Waterbury Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1264 - 1267

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Citation Number: 22

Abstract

A series of xanthone-2-carboxylic acids substituted in the 7 position with sulfamoyl and other groups was synthesized and assayed in vitro for inhibition of aldose reductase isolated from rabbit lenses. At a concentration of lo4 M, the N-methyl-N-(2-hydroxyethyl) sulfamoyl derivative 14 produced an 83% inhibition of aldose reductase. The structural requirements for this type of activity are discussed.