Anxiolytic sedatives. 1. Synthesis and pharmacology of benzo [6, 7]-1, 4-diazepino [5, 4-b] oxazole derivatives and analogs

R Tachikawa, T Miyadera, A Terada…

Index: Miyadera; Terada; Fukunaga; Kawano; Kamioka; Tamura; Takagi; Tachikawa Journal of medicinal chemistry, 1971 , vol. 14, # 6 p. 520 - 526

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Citation Number: 57

Abstract

1, IHenzodiazepine derivatives of the type la and It), synthesized by Sternbach, et aL, l have been sho\ vn to be very effective arixiolytic sedatives.* Thus, ne turned our attention for development of psychotropic agents to the synthesis of 1, 4-benzodiazepine derivatives having the new tricyclic ring system of the type I1 (X= 0 or S; iZ= straight or branched alkylene). The methodology of the molecular modification stems from an earlier\\-ork3 ...