Total synthesis of wedelolactone

…, ZX Xie, YD Zhang, JH Chen, Z Yang

Index: Li, Chuang Chuang; Xie, Zhi Xiang; Zhang, Yan Dong; Chen, Jia Hua; Yang, Zhen Journal of Organic Chemistry, 2003 , vol. 68, # 22 p. 8500 - 8504

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Citation Number: 75

Abstract

The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS-induced caspase-11 expression, using a convergent synthetic approach, is described. The key steps involved in this synthesis include the palladium- catalyzed Sonogashira reaction and the palladium-catalyzed carbonylative annulation reaction. This approach allows access to diversified analogues of wedelolactone.

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