wedelolactone

Modify Date: 2025-08-23 08:39:26

wedelolactone Structure
wedelolactone structure
 Common Name wedelolactone
CAS Number 524-12-9 Molecular Weight 314.246
Density 1.7±0.1 g/cm3 Boiling Point 498.4±45.0 °C at 760 mmHg
Molecular Formula C16H10O7 Melting Point 315 °C
MSDS Chinese USA Flash Point 255.2±28.7 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of wedelolactone


Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3].

 Names

Name wedelolactone
Synonym More Synonyms

 wedelolactone Biological Activity

Description Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3].
Related Catalog
Target

Caspase-11

5-lipoxygenase:2.5 μM (IC50)

Apoptosis

References

[1]. Kobori M, et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ. 2004 Jan;11(1):123-30.

[2]. Sarveswaran S, et al. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Int J Oncol. 2012 Dec;41(6):2191-9.

[3]. Liu YQ, et al. Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway. Sci Rep. 2016 Aug 25;6:32260.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 498.4±45.0 °C at 760 mmHg
Melting Point 315 °C
Molecular Formula C16H10O7
Molecular Weight 314.246
Flash Point 255.2±28.7 °C
Exact Mass 314.042664
PSA 113.27000
LogP 2.75
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.759
Storage condition 2-8°C
Water Solubility DMSO: 14 mg/mL, soluble

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H317
Precautionary Statements P280-P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22;R43
Safety Phrases 36/37
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles27

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Neutrophils are rapidly recruited to the site of Leishmania infection and play an active role in capturing and killing parasites. They are the main source of leukotriene B4 (LTB4), a potent proinflamm...

CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia.

Cell. Microbiol. 10(11) , 2247-56, (2008)

Bacteraemic pneumonia is a common cause of sepsis in critically ill patients today and is characterized by dysregulation of inflammation. The genetic factors predisposing to bacteraemic pneumonia are ...

Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.

Eur. J. Med. Chem. 56 , 361-7, (2012)

The anticancer properties of demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-i...

 Synonyms

6H-Benzofuro[3,2-c][1]benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy-
wedelolactone
1,8,9-Trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy-
1,8,9-trihydroxy-3-methoxycoumestan
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