Structure-based design and synthesis of small molecule protein–tyrosine phosphatase 1B inhibitors

ZJ Yao, B Ye, XW Wu, S Wang, L Wu, ZY Zhang…

Index: Yao, Zhu-Jun; Ye, Bin; Wu, Xiong-Wu; Wang, Shaomeng; Wu, Li; Zhang, Zhong-Yin; Burke Jr., Terrence R. Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 10 p. 1799 - 1810

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Citation Number: 62

Abstract

Protein–tyrosine phosphatase (PTP) inhibitors are attractive as potential signal transduction- directed therapeutics which may be useful in the treatment of a variety of diseases. We have previously reported the X-ray structure of 1, 1-difluoro-1-(2-naphthalenyl) methyl] phosphonic acid (4) complexed with the human the protein–tyrosine phosphatase 1B (PTP1B) and its use in the design of an analogue which binds with higher affinity within ...