Microwave??assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous??flow transformations

IR Baxendale, CM Griffiths??Jones…

Index: Baxendale, Ian R.; Griffiths-Jones, Charlotte M.; Ley, Steven V.; Tranmer, Geoffrey K. Chemistry - A European Journal, 2006 , vol. 12, # 16 p. 4407 - 4416

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Citation Number: 214

Abstract

Abstract This article describes the design, optimisation and development of a Suzuki cross- coupling protocol mediated by an efficient palladium-encapsulated catalyst (Pd EnCat TM) under microwave irradiation. The methodology has been used in both batch mode for classical library preparation and in continuous-flow applications furnishing multigram quantities of material. Described is a method that uses direct focused microwave heating ...

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