Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4
TB César, JA Manthey, K Myung
Index: Cesar, Thais B.; Manthey, John A.; Myung, Kyung Journal of Natural Products, 2009 , vol. 72, # 9 p. 1702 - 1704
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Citation Number: 9
Abstract
A new cyclic acetal (1) of marmin (6′, 7′-dihydroxy-7-geranyloxycoumarin), two new cyclic acetals (5, 6) of 6′, 7′-dihydroxybergamottin, and the known compounds marmin (2), 7- geranyloxycoumarin (3), bergamottin (4), and 6′, 7′-dihydroxybergamottin (7) were isolated from grapefruit peel oil. All compounds were tested for inhibitory activity against intestinal cytochrome P450 3A4, an enzyme involved in the “grapefruit/drug” interactions ...
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