COX-1/COX-2 inhibitors based on the methanone moiety

…, BL Fiebich, J Schweppenhäuser

Index: Dannhardt, Gerd; Fiebich, Bernd L; Schweppenhaeuser, Johannes European Journal of Medicinal Chemistry, 2002 , vol. 37, # 2 p. 147 - 161

Full Text: HTML

Citation Number: 29

Abstract

This paper focuses on the synthesis and the in vitro testing of dual COX-1/COX-2 inhibitors. Starting from structures of non-steroidal anti-inflammatory drugs (NSAIDs) the diaryl methanone element was chosen as a lead. Modifications were carried out on this scaffold to obtain potent inhibitors of the COX enzymes. The N-(2-aroylphenyl) sulphonamides and- amides were studied in detail, and to consolidate the data evaluated the corresponding 3- ...

Related Articles:

Identification of compounds with anti-West Nile virus activity

[Goodell, John R.; Puig-Basagoiti, Francesc; Forshey, Brett M.; Shi, Pei-Yong; Ferguson, David M. Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 2127 - 2137]

Identification of compounds with anti-West Nile virus activity

[Goodell, John R.; Puig-Basagoiti, Francesc; Forshey, Brett M.; Shi, Pei-Yong; Ferguson, David M. Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 2127 - 2137]

Cyclization of 2-azidobenzophenones to 3-phenylanthranils. Examples of an intramolecular 1, 3-dipolar addition

[Hall,J.H. et al. Journal of the American Chemical Society, 1972 , vol. 94, p. 4952 - 4958]

More Articles...