Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists

…, JH Hutchinson, J Chung, G Reyes-Manalo…

Index: Bonnefous, Celine; Vernier, Jean-Michel; Hutchinson, John H.; Chung, Janice; Reyes-Manalo, Grace; Kamenecka, Theodore Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1197 - 1200

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Citation Number: 34

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The mGlu5 receptor has been implicated in a number of CNS disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amides as small molecules mGluR5 antagonists. ... The mGlu5 receptor has been implicated in a number of CNS disorders. ...