Bioorganic & medicinal chemistry letters

Development of a novel albumin-binding prodrug that is cleaved by urokinase-type-plasminogen activator (uPA)

DE Chung, F Kratz

Index: Chung, Da-Eun; Kratz, Felix Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5157 - 5163

Full Text: HTML

Citation Number: 38

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A water-soluble albumin-binding prodrug of doxorubicin [EMC-Gly-Gly-Gly-Arg-Arg-DOXO (EMC, 6-maleimidocaproic acid)] was developed that is cleaved specifically by the tumor-associated protease urokinase-type plasminogen activator (uPA).