Organic letters

Construction of a well-defined multifunctional dendrimer for theranostics

C Ornelas, R Pennell, LF Liebes, M Weck

Index: Ornelas, Catia; Pennell, Ryan; Liebes, Leonard F.; Weck, Marcus Organic Letters, 2011 , vol. 13, # 5 p. 976 - 979

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Citation Number: 62

Abstract

A dendrimer-based building block for theranostics was designed. The multifunctional dendrimer is polyamide-based and contains nine azide termini, nine amine termini, and fifty- four terminal acid groups. Orthogonal functionalization of the multifunctional dendrimer with a near-infrared (NIR) cyanine dye afforded the final dendrimer that shows fluorescence in the NIR region and no toxicity toward T98G human cells. The synthetic strategy described ...

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