Cyclic dipeptides exhibit potency for scavenging radicals

T Furukawa, T Akutagawa, H Funatani, T Uchida…

Index: Furukawa, Tadashi; Akutagawa, Takashi; Funatani, Hitomi; Uchida, Toshikazu; Hotta, Yoshihiro; Niwa, Masatake; Takaya, Yoshiaki Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2002 - 2009

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Citation Number: 23

Abstract

Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against OH and O2·-was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against OH than vitamin E. However, only cyclo (l-Cys–l-Leu) scavenged O2·-.

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