Cyclo(-leu-pro)

Modify Date: 2024-01-02 04:40:44

Cyclo(-leu-pro) structure	Common Name	Cyclo(-leu-pro)
	CAS Number	2873-36-1	Molecular Weight	210.27
	Density	1.1±0.1 g/cm3	Boiling Point	427.6±34.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₈N₂O₂	Melting Point	163-165ºC
	MSDS	N/A	Flash Point	212.4±25.7 °C

Use of Cyclo(-leu-pro)

Cyclo(L-Leu-L-Pro) is an inhibitory substance targeting to production of norsolorinic acid (NA，a precursor of aflatoxin)，which can be isolated from A. xylosoxidans NFRI-A1. Cyclo(L-Leu-L-Pro) inhibits accumulation of NA by A. parasiticus NFRI-95 and inhibits spore formation. Cyclo(L-Leu-L-Pro) inhibits aflatoxin production with an IC50 of 0.2 mg/mL in A. parasiticus SYS-4[1].

Name	3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Synonym	More Synonyms

Description	Cyclo(L-Leu-L-Pro) is an inhibitory substance targeting to production of norsolorinic acid (NA，a precursor of aflatoxin)，which can be isolated from A. xylosoxidans NFRI-A1. Cyclo(L-Leu-L-Pro) inhibits accumulation of NA by A. parasiticus NFRI-95 and inhibits spore formation. Cyclo(L-Leu-L-Pro) inhibits aflatoxin production with an IC50 of 0.2 mg/mL in A. parasiticus SYS-4[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Yan PS, et al. Cyclo(L-leucyl-L-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus. Appl Environ Microbiol. 2004 Dec;70(12):7466-73.

Density	1.1±0.1 g/cm3
Boiling Point	427.6±34.0 °C at 760 mmHg
Melting Point	163-165ºC
Molecular Formula	C₁₁H₁₈N₂O₂
Molecular Weight	210.27
Flash Point	212.4±25.7 °C
Exact Mass	210.136826
PSA	49.41000
LogP	-0.84
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.530

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8708800

CHEMICAL NAME :: Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-isobutyl-, stereoisomer

CAS REGISTRY NUMBER :: 2873-36-1

BEILSTEIN REFERENCE NO. :: 0085716

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H18-N2-O2

MOLECULAR WEIGHT :: 210.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - facilitates action of known carcinogen

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1354,1978

HS Code	2933990090

Precursor 4
CAS#:72087-28-6 L-Leu-L-Pro-OMe CAS#:68624-06-6 (S,S)-N-Boc-leu... CAS#:51219-48-8 2-benzoyl-3-iso... CAS#:52899-07-7 H-Pro-Leu-OH
DownStream 2
CAS#:61-90-5 L-leucine CAS#:147-85-3 Proline

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Gancidin W

CYCLO(L-LEU-L-PRO)

(3S-trans)-Hexahydro-3-isobutylpyrrolo(1,2-a)pyrazine-1,4-dione

Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)-

cyclo-L-Leu-L-Pro

EINECS 220-710-6

(3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(-Leu-Pro)

GL Biochem (Shanghai) Ltd.
China
Product Name: Cyclo(-Leu-Pro)
Price: $Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

BioBioPha
China
Product Name: Cyclo(L-Leu-L-Pro)
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

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Cyclo(-leu-pro)

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