Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives

M Campos-Toimil, F Orallo, L Santana…

Index: Campos-Toimil, Manuel; Orallo, Francisco; Santana, Lourdes; Uriarte, Eugenio Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 783 - 786

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Citation Number: 73

Abstract

We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochromone that directly relaxes smooth muscle) and at a greater potency, suggesting that these compounds have a potential interest for the development of new ...