Halogenated Corticoids. I. 9α-Halogen Derivatives of Cortisone and Hydrocortisone*

J Fried, EF Sabo

Index: Fried; Sabo Journal of the American Chemical Society, 1957 , vol. 79, p. 1130,1137

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Citation Number: 93

Abstract

The synthesis of Sa-halogen derivatives of hydrocortisone and cortisone from 11-epi- hydrocortisone is described. Although originally intended as intermediates in a synthesis of hydrocortisone from its lla-epimer the main significance of these substances derives from their unusual biological properties The most potent compound, Sa-fluorohydrocortisone acetate, is obtained in an over-all yield of 26%. The preparation of Sa-halogenated ...